Cardiolipin, Mitochondria, and Neurological Disease
نویسندگان
چکیده
منابع مشابه
Biosynthesis of Cardiolipin in Plant Mitochondria.
The properties of cardiolipin synthase were investigated in mitochondria and submitochondrial fractions from etiolated mung bean (Vigna radiata L.) seedlings. Direct evidence is presented that the enzyme utilizes CDP-diacylglycerol in addition to phosphatidylglycerol for the synthesis of cardiolipin. Cardiolipin synthase had an alkaline pH optimum of about 9 and required divalent cations for ac...
متن کاملOxidative phosphorylation in cardiolipin-lacking yeast mitochondria.
The role of cardiolipin in mitochondrial energy transformation was studied by comparing oxidative phosphorylation in the Saccharomyces cerevisiae cardiolipin synthase null mutant crd1Delta, and in isogenic wild type. Oxygen consumption experiments and membrane potential kinetics during the phosphorylation cycle in isolated mitochondria indicated that the absence of cardiolipin causes only a mod...
متن کاملCardiolipin as key lipid of mitochondria in health and disease, Bari, Italy, September 17, 2013
The idea of a Cardiolipin workshop in Italy came to the meeting organizers in June 2011, during the mini‐ sabbatical of Angela Corcelli in New York City in the Laboratory of Michael Schlame. They thought to take advantage of the presence of the 54th International Conference on the Bioscience of Lipids (ICBL) at Bari in 2013 to organize the Cardiolipin workshop as a satellite event. The web page...
متن کاملCardiolipin mediates cross-talk between mitochondria and the vacuole.
Cardiolipin (CL) is an anionic phospholipid with a dimeric structure predominantly localized in the mitochondrial inner membrane, where it is closely associated with mitochondrial function, biogenesis, and genome stability (Daum, 1985; Janitor and Subik, 1993; Jiang et al., 2000; Schlame et al., 2000; Zhong et al., 2004). Previous studies have shown that yeast mutant cells lacking CL due to a d...
متن کاملUps1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria
Cardiolipin, a unique phospholipid composed of four fatty acid chains, is located mainly in the mitochondrial inner membrane (IM). Cardiolipin is required for the integrity of several protein complexes in the IM, including the TIM23 translocase, a dynamic complex which mediates protein import into the mitochondria through interactions with the import motor presequence translocase-associated mot...
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ژورنال
عنوان ژورنال: Trends in Endocrinology & Metabolism
سال: 2021
ISSN: 1043-2760
DOI: 10.1016/j.tem.2021.01.006